Continuous Selective Hydrogenation of Refametinib lodo-nitroaniline Key Intermediate DIM-NA over Raney Cobalt Catalyst at kg/day Scale with Online UV-Visible Conversion Control

Ben Said, M; Baramov, T; Herrmann, T; Gottfried, M; Hassfeld, J; Roggan, S

Roggan, S (reprint author), Bayer AG, Pharmaceut Div, D-42096 Wuppertal, Germany.

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2017; 21 (5): 705

Abstract

The continuous selective hydrogenation of the iodo-nitroaromatic refametinib active pharmaceutical ingredient (API) intermediate (2,3-difluoro-5-metho......

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