Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke

Tuo, QZ; Liuyang, ZY; Lei, P; Yan, X; Shentu, YP; Liang, JW; Zhou, H; Pei, L; Xiong, Y; Hou, TY; Zhou, XW; Wang, Q; Wang, JZ; Wang, XC; Liu, R

Liu, R (reprint author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathophysiol,Key Lab,Minist Educ Neurol Diso, Wuhan, Hubei, Peoples R China.

CELL DEATH & DISEASE, 2018; 9 ():

Abstract

CDK5 activation promotes ischemic neuronal death in stroke, with the recognized activation mechanism being calpain-dependent p35 cleavage to p25. Here......

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