Computational evolution of an RNA-binding protein towards enhanced oxidized-RNA binding

Gonzalez-Rivera, JC; Orr, AA; Engels, SM; Jakubowski, JM; Sherman, MW; O'Connor, KN; Matteson, T; Woodcock, BC; Contreras, LM; Tamamis, P

Contreras, LM (corresponding author), Univ Texas Austin, McKetta Dept Chem Engn, 200 E Dean Keeton St Stop C0400, Austin, TX 78712 USA.; Tamamis, P (corresponding author), Texas A&M Univ, Artie McFerrin Dept Chem Engn, 3122 TAMU Room 200, College Stn, TX 77843 USA.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2020; 18 (): 137

Abstract

The oxidation of RNA has been implicated in the development of many diseases. Among the four ribonucleotides, guanosine is the most susceptible to oxi......

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