Evolution of chalcone isomerase from a noncatalytic ancestor

Kaltenbach, M; Burke, JR; Dindo, M; Pabis, A; Munsberg, FS; Rabin, A; Kamerlin, SCL; Noel, JP; Tawfik, DS

Tawfik, DS (reprint author), Weizmann Inst Sci, Dept Biol Chem, Rehovot, Israel.; Noel, JP (reprint author), Salk Inst Biol Studies, Howard Hughes Med Inst, Jack H Skirball Ctr Chem Biol & Prote, La Jolla, CA 92037 USA.

NATURE CHEMICAL BIOLOGY, 2018; 14 (6): 548

Abstract

The emergence of catalysis in a noncatalytic protein scaffold is a rare, unexplored event. Chalcone isomerase (CHI), a key enzyme in plant flavonoid b......

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