The Metabolite Saccharopine Impairs Neuronal Development by Inhibiting the Neurotrophic Function of Glucose-6-Phosphate Isomerase

Guo, Y; Wu, JJ; Wang, M; Wang, X; Jian, YL; Yang, CL; Guo, WX

Guo, WX (通讯作者)，Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China.;Guo, WX (通讯作者)，Univ Chinese Acad Sci, Grad Sch, Beijing 100093, Peoples R China.

JOURNAL OF NEUROSCIENCE, 2022; 42 (13): 2631

Abstract

Mutations in the Aminoadipate-Semialdehyde Synthase (AASS) gene encoding a-aminoadipic semialdehyde synthase lead to hyperlysinemia-I, a benign metabo......

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