Naturally occurring core protein mutations compensate for the reduced replication fitness of a lamivudine-resistant HBV isolate

Zhang, YM; Zhang, H; Zhang, JJ; Zhang, JM; Guo, HT

Guo, HT (reprint author), Indiana Univ Sch Med, 635 Barnhill Dr, Indianapolis, IN 46202 USA.; Zhang, JM (reprint author), Fudan Univ, Huashan Hosp, 12 Middle Wulumuqi Rd, Shanghai 200040, Peoples R China.

ANTIVIRAL RESEARCH, 2019; 165 (): 47

Abstract

Hepatitis B virus (HBV) replicates its DNA genome through reverse transcription of an RNA intermediate. The lack of proofreading capacity of the viral......

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