Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab

Wijnsma, KL; ter Heine, R; Moes, DJAR; Langemeijer, S; Schols, SEM; Volokhina, EB; van den Heuvel, LP; Wetzels, JFM; van de Kar, NCAJ; Bruggemann, RJ

Wijnsma, KL (reprint author), Radboud Univ Nijmegen, Radboud Inst Mol Life Sci, Amalia Childrens Hosp, Dept Pediat Nephrol,Med Ctr, POB 9101, NL-6500 HB Nijmegen, Netherlands.

CLINICAL PHARMACOKINETICS, 2019; 58 (7): 859

Abstract

Eculizumab is the first drug approved for the treatment of complement-mediated diseases, and current dosage schedules result in large interindividual ......

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