Simultaneous quantification of the CYP2D6 substrate yohimbine, its metabolite 11-OH-yohimbine, and the CYP2D6 inhibitor paroxetine in human plasma

Vay, M; Skopp, G; Mikus, G; Burhenne, J

Burhenne, J (reprint author), Heidelberg Univ Hosp, Dept Clin Pharmacol & Pharmacoepidemiol, Neuenheimer Feld 410, D-69120 Heidelberg, Germany.

ANALYTICAL METHODS, 2019; 11 (47): 5976

Abstract

We developed and validated a human plasma LC-MS/MS assay according to FDA guidelines to determine the impact of the CYP2D6 inhibitor paroxetine on the......

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