Kinase activity of mutant LRRK2 manifests differently in hetero-dimeric vs. homo-dimeric complexes

Leandrou, E; Markidi, E; Memou, A; Melachroinou, K; Greggio, E; Rideout, HJ

Rideout, HJ (reprint author), Acad Athens, Lab Neurodegenerat Dis, Div Basic Neurosci, Biomed Res Fdn, Athens 11527, Greece.

BIOCHEMICAL JOURNAL, 2019; 476 (): 559

Abstract

The Parkinson's disease (PD) protein leucine-rich repeat kinase 2 (LRRK2) exists as a mixture of monomeric and dimeric species, with its kinase activi......

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