Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism

Su, L; Zhang, XL; Zheng, L; Wang, MM; Zhu, ZF; Li, P

Li, P (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Dept Integrated Tradit & Western Med Oncol, Hefei, Peoples R China.

FRONTIERS IN ENDOCRINOLOGY, 2020; 11 ():

Abstract

Aim: Isocitrate dehydrogenase 1 (IDH1) is key enzyme involved in cellular metabolism and DNA repair. Mutations in IDH1 occur in up to 25% of cholangio......

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