Ubiquitin Ligase Activities of WWP1 Germline Variants K740N and N745S

Jiang, HJ; Dempsey, DR; Cole, PA

Cole, PA (corresponding author), Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Div Genet, Dept Med,Brigham & Womens Hosp, Boston, MA 02115 USA.; Cole, PA (corresponding author), Johns Hopkins Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA.

BIOCHEMISTRY, 2021; 60 (5): 357

Abstract

WWP1 is an E3 ubiquitin ligase that has been reported to target the tumor suppressor lipid phosphatase PTEN. K740N and N745S are recently identified g......

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