Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase

Andriianov, A; Trigüis, S; Drobiazko, A; Sierro, N; Ivanov, N; Selmer, M; Severínov, K; Isaev, A

Isaev, A (通讯作者)，Skolkovo Inst Sci & Technol, Moscow 143028, Russia.;Selmer, M (通讯作者)，Uppsala Univ, Dept Cell & Mol Biol, BMC, Box 596, S-75124 Uppsala, Sweden.;Severínov, K (通讯作者)，Waksman Inst Microbiol, Piscataway, NJ 08854 USA.

CELL REPORTS, 2023; 42 (8):

Abstract

Bacteriophage T3 encodes a SAMase that, through cleavage of S-adenosyl methionine (SAM), circumvents the SAM-dependent type I restriction-modification......

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