The Intra-nuclear SphK2-S1P Axis Facilitates M1-to-M2 Shift of Microglia via Suppressing HDAC1-Mediated KLF4 Deacetylation

Ji, J; Wang, J; Yang, J; Wang, XP; Huang, JJ; Xue, TF; Sun, XL

Sun, XL (reprint author), Nanjing Med Univ, Neuroprotect Drug Discovery Key Lab, Dept Pharmacol, Nanjing, Jiangsu, Peoples R China.; Sun, XL (reprint author), Nanjing Med Univ, Dept Pharmacol, Jiangsu Key Lab Neurodegenerat, Nanjing, Jiangsu, Peoples R Ch

FRONTIERS IN IMMUNOLOGY, 2019; 10 ():

Abstract

Sphingosine 1-phosphate (S1P) is involved in a variety of cellular responses including microglial activation and polarization. However, the impacts of......

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