Directed Evolution of a G-Quadruplex Peroxidase DNAzyme and Application in Proteomic DNAzyme-Aptamer Proximity Labeling

Bhuyan, SK; Wang, L; Jinata, C; Kinghorn, AB; Liu, MP; He, WS; Sharma, R; Tanner, JA

Tanner, JA (通讯作者)，Univ Hong Kong, LKS Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China.;Tanner, JA (通讯作者)，Adv Biomed Instrumentat Ctr, Hong Kong, Peoples R China.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023; 145 (23): 12726

Abstract

DNAzymeshave been limited in application by their lowcatalyticrates. Here, we evolved a new peroxidase DNAzyme mSBDZ-X-3 througha directed evolution m......

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