SCN5A Mutation Type and a Genetic Risk Score Associate Variably With Brugada Syndrome Phenotype in SCN5A Families

Wijeyeratne, YD; Tanck, MW; Mizusawa, Y; Batchvarov, V; Barc, J; Crotti, L; Bos, JM; Tester, DJ; Muir, A; Veltmann, C; Ohno, S; Page, SP; Galvin, J; Tadros, R; Muggenthaler, M; Raju, H; Denjoy, I; Schott, JJ; Gourraud, JB; Skoric-Milosavljevic, D; Nannenberg, EA; Redon, R; Papadakis, M; Kyndt, F; Dagradi, F; Castelletti, S; Torchio, M; Meitinger, T; Lichtner, P; Ishikawa, T; Wilde, AAM; Takahashi, K; Sharma, S; Roden, DM; Borggrefe, MM; McKeown, PP; Shimizu, W; Horie, M; Makita, N; Aiba, T; Ackerman, MJ; Schwartz, PJ; Probst, V; Bezzina, CR; Behr, ER

Behr, ER (corresponding author), St Georges Univ London, St Georges Univ Hosp NHS Fdn Trust, Cardiol Clin Acad Grp, London, England.

CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2020; 13 (6): 599

Abstract

Background: Brugada syndrome (BrS) is characterized by the type 1 Brugada ECG pattern. Pathogenic rare variants in SCN5A (mutations) are identified in......

Full Text Link