Enantioselective Synthesis of 4 '-Ethynyl-2-fluoro-2 '-deoxyadenosine (EFdA) via Enzymatic Desymmetrization

McLaughlin, M; Kong, J; Belyk, KM; Chen, B; Gibson, AW; Keen, SP; Lieberman, DR; Milczek, EM; Moore, JC; Murray, D; Peng, F; Qi, J; Reamer, RA; Song, ZJ; Tan, LS; Wang, L; Williams, MJ

McLaughlin, M; Kong, J (reprint author), Merck & Co Inc, MRL, Dept Proc Res & Dev, Rahway, NJ 07065 USA.

ORGANIC LETTERS, 2017; 19 (4): 926

Abstract

An enantioselective synthesis of the potent anti-HIV nucleoside EFdA is presented. Key features of stereo control include construction of the fully su......

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