HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

Kijima, T; Prince, TL; Tigue, ML; Yim, KH; Schwartz, H; Beebe, K; Lee, S; Budzynski, MA; Williams, H; Trepel, JB; Sistonen, L; Calderwood, S; Neckers, L

Prince, TL; Neckers, L (reprint author), NCI, Urol Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.; Prince, TL (reprint author), Geisinger Med Clin, Urol Dept, WCR 221, Danville, PA 17821 USA.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional pro......

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