Structure of nevanimibe-bound tetrameric human ACAT1

Long, T; Sun, YY; Hassan, A; Qi, XF; Li, XC

Li, XC (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA.; Li, XC (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Biophys, Dallas, TX 75390 USA.

NATURE, 2020; 581 (7808): 339

Abstract

The structure of human ACAT1 in complex with the inhibitor nevanimibe is resolved by cryo-electron microscopy. Cholesterol is an essential component o......

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