Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension

Hanna, A; Shinde, AV; Li, RS; Alex, L; Humeres, C; Balasubramanian, P; Frangogiannis, NG

Frangogiannis, NG (corresponding author), Albert Einstein Coll Med, Wilf Family Cardiovasc Res Inst, Dept Med Cardiol, Morris Pk Ave Forchheimer G46B, Bronx, NY 10461 USA.

MATRIX BIOLOGY, 2021; 99 (): 18

Abstract

Tissue injury results in profound alterations in the collagen network, associated with unfolding of the collagen triple helix, proteolytic degradation......

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