Quantitative Prediction of Human Hepatic Clearance for P450 and Non-P450 Substrates from In Vivo Monkey Pharmacokinetics Study and In Vitro Metabolic Stability Tests Using Hepatocytes

Nishimuta, H; Watanabe, T; Bando, K

Nishimuta, H (reprint author), Sumitomo Dainippon Pharma Co Ltd, Preclin Res Unit, Konohana Ku, 3-1-98 Kasugade Naka, Osaka 5540022, Japan.

AAPS JOURNAL, 2019; 21 (2):

Abstract

Accurate prediction of human pharmacokinetics for drugs remains challenging, especially for non-cytochrome P450 (P450) substrates. Hepatocytes might b......

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