Generation of An Endogenous FGFR2-BICC1 Gene Fusion/58 Megabase Inversion Using Single-Plasmid CRISPR/Cas9 Editing in Biliary Cells

Reicher, A; Harris, AL; Prinz, F; Kiesslich, T; Wei, MY; Ollinger, R; Rad, R; Pichler, M; Kwong, LN

Pichler, M (corresponding author), Med Univ Graz, Div Oncol, A-8036 Graz, Austria.; Pichler, M (corresponding author), Med Univ Graz, Res Unit Noncoding RNA & Genome Editing, A-8036 Graz, Austria.; Kwong, LN (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020; 21 (7):

Abstract

Fibroblast growth factor receptor 2 (FGFR2) gene fusions are bona fide oncogenic drivers in 10-15% of intrahepatic cholangiocarcinoma (CCA), yet curre......

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