Defective jagged-1 signaling affects GnRH development and contributes to congenital hypogonadotropic hypogonadism

Cotellessa, L; Marelli, F; Duminuco, P; Adamo, M; Papadakis, GE; Bartoloni, L; Sato, N; Lang-Muritano, M; Troendle, A; Dhillo, WS; Morelli, A; Guarnieri, G; Pitteloud, N; Persani, L; Bonomi, M; Giacobini, P; Vezzoli, V

Giacobini, P (通讯作者)，Lille Neurosci & Cognit, Lab Dev & Plast Neuroendocrine Brain, UMR S 1172, 1 Pl Verdun, F-59045 Lille, France.;Vezzoli, V (通讯作者)，Lab Endocrine & Metab Res, Via Zucchi 18, I-20095 Milan, Italy.

JCI INSIGHT, 2023; 8 (5):

Abstract

In vertebrate species, fertility is controlled by gonadotropin-releasing hormone (GnRH) neurons. GnRH cells arise outside the central nervous system, ......

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