High-Dose IV Administration of Rasburicase Suppresses Anti-rasburicase Antibodies, Depletes Rasburicase-Specific Lymphocytes, and Upregulates Treg Cells

Xu, H; Feldman, GM; Max, EE

Feldman, GM (corresponding author), US FDA, Lab Immunobiol, Off Biotechnol Prod, Ctr Drug Evaluat & Res, Bldg 72 Room 2324,10903 New Hampshire Ave, Silver Spring, MD 20993 USA.

AAPS JOURNAL, 2020; 22 (4):

Abstract

Therapeutic proteins can be potent agents for treating serious diseases, but in many patients these proteins provoke antibody responses that blunt the......

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