Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression

Malnassy, G; Keating, CR; Gad, S; Bridgeman, B; Perera, A; Hou, W; Cotler, SJ; Ding, XZ; Choudhry, M; Sun, ZL; Koleske, AJ; Qiu, W

Qiu, W (通讯作者)，Loyola Univ, Chicago Stritch Sch Med, Dept Surg, Maywood, IL USA.;Qiu, W (通讯作者)，Loyola Univ Chicago, Stritch Sch Med, Dept Canc Biol, Maywood, IL USA.;Qiu, W (通讯作者)，Loyola Univ Chicago, Dept Surg, 2160 South 1st Ave,Bldg 112 Room 338, Maywood, IL 60153 USA.;Qiu, W (通讯作者)，Loyola Univ Chicago, Dept Canc Biol, 2160 South 1st Ave,Bldg 112 Room 338, Maywood, IL 60153 USA.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2023; 16 (5): 685

Abstract

We found that the knockout of Abl2, but not Abl1, abrogated alcohol-induced steatosis, liver injury, and inflammation in mice. Mechanistically, we fou......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索