Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Linden, D; Ahnmark, A; Pingitore, P; Ciociola, E; Ahlstedt, I; Andreasson, AC; Sasidharan, K; Madeyski-Bengtson, K; Zurek, M; Mancina, RM; Lindblom, A; Bjursell, M; Bottcher, G; Stahlman, M; Bohlooly-Y, M; Haynes, WG; Carlsson, B; Graham, M; Lee, R;

Romeo, S (reprint author), Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.; Linden, D (reprint author), AstraZeneca Gothenburg, IMED Biotech Unit, Cardiovasc Renal & Metab, SE-43183 Molndal, Sweden.

MOLECULAR METABOLISM, 2019; 22 (): 49

Abstract

Objective: Nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of advanced chronic liver disease. The progression of NAFLD, including......

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