Hypermethylation of CD19 promoter enables antigen-negative escape to CART-19 in vivo and in vitro

Ledererova, A; Dostalova, L; Kozlova, V; Peschelova, H; Ladungova, A; Culen, M; Loja, T; Verner, J; Pospisilova, S; Smida, M; Mancikova, V

Smida, M; Mancikova, V (corresponding author), Masaryk Univ, Cent European Inst Technol, Brno, Czech Republic.; Smida, M; Mancikova, V (corresponding author), Masaryk Univ, Dept Internal Med Oncol & Hematol, Univ Hosp Brno, Brno, Czech Republic.; Smida, M; Mancikova, V (corresponding author), Masaryk Univ, Fac Med, Brno, Czech Republic.

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021; 9 (8):

Abstract

Background Anti-CD19 chimeric antigen receptor T cells (CART-19) frequently induce remissions in hemato-oncological patients with recurred and/or refr......

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