ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S; Proneth, B; Tyurina, YY; Panzilius, E; Kobayashi, S; IngoId, I; Irmler, M; Beckers, J; Aichler, M; Walch, A; Prokisch, H; Trumbach, D; Mao, GW; Qu, F; Bayir, H; Fullekrug, J; Scheel, CH; Wurst, W; Schick, JA; Kagan, VE; Angeli, JPF; Conrad,

Angeli, JPF; Conrad, M (reprint author), Helmholtz Zentrum Munchen, Inst Dev Genet, Neuherberg, Germany.

NATURE CHEMICAL BIOLOGY, 2017; 13 (1): 91

Abstract

Ferroptosis is a form of regulated necrotic cell death controlled by glutathione peroxidase 4 (GPX4). At present, mechanisms that could predict sensit......

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