PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1(+)CD38(hi) cells and anti-PD-1 resistance

Verma, V; Shrimalim, RK; Ahmadm, S; Dai, WJ; Wang, H; Lu, SM; Nandrelm, R; Gaur, P; Lopez, J; Sade-Feldman, M; Yizhak, K; Bjorgaard, SL; Flaherty, KT; Wargo, JA; Boland, GM; Sullivan, RJ; Getz, G; Hammond, SA; Tan, M; Qi, JJ; Wong, P; Merghoub, T; Wo

Khleif, SN (reprint author), Augusta Univ, Georgia Canc Ctr, Augusta, GA 30912 USA.; Khleif, SN (reprint author), Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA.

NATURE IMMUNOLOGY, 2019; 20 (9): 1231

Abstract

Understanding resistance to antibody to programmed cell death protein 1 (PD-1; anti-PD-1) is crucial for the development of reversal strategies. In an......

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