DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters

Sutton, MN; Lu, Z; Li, YC; Zhou, Y; Huang, T; Reger, AS; Hurwitz, AM; Palzkill, T; Logsdon, C; Liang, XW; Gray, JW; Nan, XL; Hancock, J; Wahl, GM; Bast, RC

Bast, RC (reprint author), Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA.

CELL REPORTS, 2019; 29 (11): 3448

Abstract

Oncogenic RAS mutations drive cancers at many sites. Recent reports suggest that RAS dimerization, multimerization, and clustering correlate strongly ......

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