A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS

Bery, N; Miller, A; Rabbitts, T

Rabbitts, T (corresponding author), Univ Oxford, John Radcliffe Hosp, MRC, Weatherall Inst Mol Med,Mol Haematol Unit, Oxford OX3 9DS, England.; Rabbitts, T (corresponding author), Inst Canc Res, Div Canc Therapeut, 15 Cotswold Rd, London SM2 5NG, England.

NATURE COMMUNICATIONS, 2020; 11 (1):

Abstract

Tumour-associated KRAS mutations are the most prevalent in the three RAS-family isoforms and involve many different amino-acids. Therefore, molecules ......

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