Improved 11 alpha-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus

Li, QQ; Shi, L; Liu, YY; Guan, SM; Zhang, S; Cai, BG; Rong, SF

Rong, SF (corresponding author), Shanghai Inst Technol, Dept Bioengn, Shanghai 201418, Peoples R China.

ACTA PHARMACEUTICA, 2021; 71 (1): 99

Abstract

Eplerenone is a drug that protects the cardiovascular system. 11 alpha-Hydroxycanrenone is a key intermediate in eplerenone synthesis. We found that a......

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