Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis

Hou, SH; Yang, XP; Tong, Y; Yang, YJ; Chen, QW; Wan, BH; Wei, R; Wang, YC; Zhang, YM; Kong, B; Huang, JH; Chen, YD; Lu, T; Hu, QH; Du, D

Lu, T; Du, D (corresponding author), China Pharmaceut Univ, Sch Sci, 639 Longmian Ave, Nanjing 211198, Peoples R China.; Hu, QH (corresponding author), China Pharmaceut Univ, Sch Pharm, 639 Longmian Ave, Nanjing 211198, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021; 211 ():

Abstract

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) family, is implicated in many human diseases. Her......

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