Pre-treatment with high molecular weight free PEG effectively suppresses anti-PEG antibody induction by PEG-liposomes in mice

McSweeney, MD; Shen, LM; DeWalle, AC; Joiner, JB; Ciociola, EC; Raghuwanshi, D; Macauley, MS; Lai, SK

Lai, SK (corresponding author), Univ N Carolina, Div Pharmacoengn & Mol Pharmaceut, Eshelman Sch Pharm, Chapel Hill, NC 27515 USA.

JOURNAL OF CONTROLLED RELEASE, 2021; 329 (): 774

Abstract

Immune responses against polyethylene glycol (PEG) can lead to the rapid clearance of PEGylated drugs and are associated with increased risk of seriou......

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