Structures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography

Kwon, YD; Wang, XCE; Bender, MF; Yang, R; Li, YL; McKee, K; Rawi, R; O'Dell, S; Schneck, NA; Shaddeau, A; Zhang, BS; Arnold, FJ; Connors, M; Doria-Rose, NA; Kwong, PD; Lei, QP

Kwong, PD (corresponding author), Natl Inst Hlth, Natl Inst Allergy & Infect Dis, Vaccine Res Ctr, Bethesda, MD 20892 USA.; Lei, QP (corresponding author), Natl Inst Hlth, Natl Inst Allergy & Infect Dis, Vaccine Res Ctr, Vaccine Prod Program, Gaithersburg, MD 20878 USA.

ANTIBODIES, 2021; 10 (2):

Abstract

Antibody 10E8 is capable of effectively neutralizing HIV through its recognition of the membrane-proximal external region (MPER), and a suitably optim......

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