Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator

Zhang, B; Wang, Y; Huang, SL; Sun, JQ; Wang, M; Ma, WX; You, YB; Wu, L; Hu, J; Song, W; Liu, XD; Li, SJ; Chen, H; Zhang, GS; Zhang, LH; Zhou, DM; Li, LJ; Zhang, X

Zhou, DM (corresponding author), Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China.; Zhang, X (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Clin Immunol Ctr & Epigenet Ctr, Beijing 100730, Peoples R China.; Li, LJ (corresponding author), Henan Normal Univ, Henan Key Lab Organ Funct Mol & Drug Innovat, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China.; Zhang, X (corresponding author), Chinese Acad Med Sci & Pe

CELL CHEMICAL BIOLOGY, 2021; 28 (1): 60

Abstract

Chimeric antigen receptor (CAR)-T-based therapeutics are a breakthrough in cancer treatment; however, they are hampered by constitutive activation, wh......

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