Impaired IFN gamma-Signaling and Mycobacterial Clearance in IFN gamma R1-Deficient Human iPSC-Derived Macrophages

Neehus, AL; Lam, J; Haake, K; Merkert, S; Schmidt, N; Mucci, A; Ackermann, M; Schubert, M; Happle, C; Kuhnel, MP; Blank, P; Philipp, F; Goethe, R; Jonigk, D; Martin, U; Kalinke, U; Baumann, U; Schambach, A; Roesler, J; Lachmann, N

Lachmann, N (reprint author), Hannover Med Sch, Inst Expt Hematol, Carl Neuberg Str 1, D-30625 Hannover, Germany.; Lachmann, N (reprint author), Hannover Med Sch, REBIRTH Cluster Excellence, D-30625 Hannover, Germany.

STEM CELL REPORTS, 2018; 10 (1): 7

Abstract

Mendelian susceptibility to mycobacterial disease (MSMD) is caused by inborn errors of interferon gamma (IFN gamma) immunity and is characterized by s......

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