Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas

Patel, YT; Daryani, VM; Patel, P; Zhou, D; Fangusaro, J; Carlile, DJ; Martin, PD; Aarons, L; Stewart, CF

Stewart, CF (reprint author), St Jude Childrens Res Hosp, Dept Pharmaceut Sci, 332 N Lauderdale St, Memphis, TN 38105 USA.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2017; 6 (5): 305

Abstract

Selumetinib (AZD6244, ARRY-142886), a mitogen activated protein kinases (MEK1 and 2) inhibitor, has been granted orphan drug designation for different......

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