Egr2 and 3 Inhibit T-bet-Mediated IFN-gamma Production in T Cells

Singh, R; Miao, TZ; Symonds, ALJ; Omodho, B; Li, SL; Wang, P

Wang, P (reprint author), Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, 4 Newark St, London E1 2AT, England.; Li, SL (reprint author), Brunel Univ London, Biosci, Kingston Lane, Uxbridge UB8 3PH, Middx, England.

JOURNAL OF IMMUNOLOGY, 2017; 198 (11): 4394

Abstract

T-bet is important for differentiation of cytotoxic CD8 and Th1 CD4 T cells. We have discovered that Egr2 and 3 are potent inhibitors of T-bet functio......

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