A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia

Ramsey, HE; Fischer, MA; Lee, T; Gorskal, AE; Arratel, MP; Fuller, L; Boyd, KL; Strickland, SA; Sensintaffar, J; Hogdal, LJ; Ayerss, GD; Olejniczak, ET; Fesik, SW; Savona, MR

Savona, MR (reprint author), Vanderbilt Univ, Sch Med, 777 Preston Res Bldg,2200 Pierce Ave, Nashville, TN 37232 USA.

CANCER DISCOVERY, 2018; 8 (12): 1566

Abstract

Suppression of apoptosis by expression of antiapoptotic BCL2 family members is a hallmark of acute myeloblastic leukemia (AML). Induced myeloid leukem......

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