Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics

Tambo, CS; Tripathi, S; Perera, BGK; Maly, DJ; Bridges, AJ; Kiss, G; Rubin, SM

Rubin, SM (通讯作者),Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA.

ACS CHEMICAL BIOLOGY, 2023; ():

Abstract

Cyclin-dependent kinases (CDKs) are key mediators of cell proliferation and have been a subject of oncology drug discovery efforts for over two decade......

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