mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation

Chornoguz, O; Hagan, RS; Haile, A; Arwood, ML; Gamper, CJ; Banerjee, A; Powell, JD

Powell, JD (reprint author), Johns Hopkins Univ, Sch Med, 1650 Orleans St, Baltimore, MD 21287 USA.

JOURNAL OF IMMUNOLOGY, 2017; 198 (10): 3939

Abstract

CD4(+) T cells lacking the mTORC1 activator Rheb fail to secrete IFN-gamma under Th1 polarizing conditions. We hypothesized that this phenotype is due......

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