Nonregistration, discontinuation, and nonpublication of randomized trials: A repeated metaresearch analysis

Speich, BL; Gryaznov, D; Busse, J; Gloy, V; Lohner, S; Klatte, K; Heravi, AT; Ghosh, NR; Lee, HP; Mansouri, A; Marian, I; Saccilotto, R; Nury, E; Kasenda, B; Ojeda-Ruiz, E; Schandelmaier, S; Tomonaga, Y; Amstutz, A; Pauli-Magnus, C; Bischoff, KJ; Wollmann, K; Rehner, L; Meerpohl, J; Nordmann, A; Wong, JCLE; Chow, N; Hong, PJ; De Iaco, K; Sricharoenchai, SG; Agarwal, A; Schwenkglenks, M; Hemkens, LN; von Elm, E; Copsey, B; Griessbach, A; Schoenenberger, C; Mertz, D; Bluemle, A; von Niederhaeusern, B; Hopewell, S; Odutayo, A; Briel, M; Davidson, C

PLOS MEDICINE, 2022; 19 (4):

Abstract

Background We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, and 4......

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