Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure

Hutchens, S; Jursa, TP; Melkote, A; Grant, SM; Smith, DR; Mukhopadhyay, S

Mukhopadhyay, S (通讯作者)，Univ Texas Austin, Inst Neurosci, Coll Pharm, Div Pharmacol & Toxicol, Austin, TX 78712 USA.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2023; 325 (3): G251

Abstract

Manganese (Mn) is essential but neurotoxic at elevated levels. Under physiological conditions, Mn is primarily excreted by the liver, with the intesti......

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