Abnormal striatal plasticity in a DYT11/SGCE myoclonus dystonia mouse model is reversed by adenosine A2A receptor inhibition

Maltese, M; Martella, G; Imbriani, P; Schuermans, J; Billion, K; Sciamanna, G; Farook, F; Ponterio, G; Tassone, A; Santoro, M; Bonsi, P; Pisani, A; Goodchild, RE

Pisani, A (reprint author), Univ Roma Tor Vergata, Dept Syst Med, Via Montpellier, I-00133 Rome, Italy.; Goodchild, RE (reprint author), KU, VIB KU Leuven Ctr Brain & Dis Res, Dept Neurosci, Campus Gasthuisberg, B-3000 Leuven, Leuven, Belgium.

NEUROBIOLOGY OF DISEASE, 2017; 108 ( ): 128

Abstract

Striatal dysfunction is implicated in many movement disorders. However, the precise nature of defects often remains uncharacterized, which hinders the......

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