Clonal Evolution of Autoreactive Germinal Centers

Degn, SE; van der Poel, CE; Firl, DJ; Ayoglu, B; Al Qureshah, FA; Bajic, G; Mesin, L; Reynaud, CA; Weill, JC; Utz, PJ; Victora, GD; Carroll, MC

Degn, SE; Carroll, MC (reprint author), Harvard Med Sch, Boston Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA.; Degn, SE (reprint author), Aarhus Univ, Dept Biomed, DK-8000 Aarhus C, Denmark.

CELL, 2017; 170 (5): 913

Abstract

Germinal centers (GCs) are the primary sites of clonal B cell expansion and affinity maturation, directing the production of high-affinity antibodies.......

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