Pt(IV) hybrids containing a TDO inhibitor serve as potential anticancer immunomodulators

Hua, SX; Chen, FH; Wang, XY; Wang, YJ; Gou, SH

Gou, SH (reprint author), Southeast Univ, Pharmaceut Res Ctr, Nanjing 211189, Jiangsu, Peoples R China.; Gou, SH (reprint author), Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China.

JOURNAL OF INORGANIC BIOCHEMISTRY, 2019; 195 (): 130

Abstract

Tryptophan 2,3-dioxygenase (TDO), an immunosuppressive enzyme, can involve in immune evasion and tumor tolerance. TDO inhibitors can boost the efficac......

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