Coordinated regulation of hepatic FoxO1, PGC-1 alpha and SREBP-1c facilitates insulin action and resistance

Sajan, MP; Lee, MC; Foufelle, F; Sajan, J; Cleland, C; Farese, RV

Farese, RV (reprint author), James A Haley Vet Med Ctr, Res Serv 151, 13000 Bruce B Downs Blvd, Tampa, FL 33612 USA.

CELLULAR SIGNALLING, 2018; 43 (): 62

Abstract

Type 2 diabetes is characterized by insulin resistance, hyperinsulinemia and hepatic overproduction of glucose and lipids. Insulin increases lipogenic......

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