Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

Duan, LR; Zaepfel, BL; Aksenova, V; Dasso, M; Rothstein, JD; Kalab, P; Hayes, LR

Hayes, LR (通讯作者)，Johns Hopkins Univ, Brain Sci Inst, Sch Med, Baltimore, MD 21205 USA.;Hayes, LR (通讯作者)，Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21205 USA.;Kalab, P (通讯作者)，Johns Hopkins Univ, Whiting Sch Engn, Dept Chem & Biomol Engn, Baltimore, MD 21218 USA.

CELL REPORTS, 2022; 40 (3):

Abstract

Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration and an important therapeutic target. Our current understanding ......

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