Discovery and Structural Basis of the Selectivity of Potent CyclicPeptide Inhibitors of MAGE-A4

Fleming, MC; Chiou, LF; Tumbale, PP; Droby, GN; Lim, J; Norris-Drouin, JL; Williams, JG; Pearce, KH; Williams, RS; Vaziri, C; Bowers, AA

Bowers, AA (通讯作者)，Univ N Carolina, Div Chem Biol & Med Chem, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA.;Bowers, AA (通讯作者)，Univ N Carolina, Ctr Integrat Chem Biol & Drug Discovery, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA.;Bowers, AA (通讯作者)，Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA.

JOURNAL OF MEDICINAL CHEMISTRY, 2022; 65 (10): 7231

Abstract

MAGE proteins are cancer testis antigens (CTAs) thatare characterized by highly conserved MAGE homology domains(MHDs) and are increasingly being found......

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