A MedChem toolbox for cereblon-directed PROTACs

Steinebach, C; Sosic, I; Lindner, S; Bricelj, A; Kohl, F; Ng, YLD; Monschke, M; Wagner, KG; Kronke, J; Gutschow, M

Gutschow, M (reprint author), Univ Bonn, Inst Pharmaceut, Pharmaceut Chem 1, Immenburg 4, D-53121 Bonn, Germany.

MEDCHEMCOMM, 2019; 10 (6): 1037

Abstract

A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position o......

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